Keynote Video
Complications and Side Effects
Local injection site reactions are the most common adverse events associated with soft tissue augmentation. The potential for bruises is influenced by the needle size, the site of injection, the technique and speed of injection, and by the product choice. It is generally believed that biodegradable agents stimulate neocollagenesis for sustained aesthetic improvements with minimal side effects.
The most commonly seen complications observed in Italian clinical practice following the injection of PN-HPT™-based dermal gels are erythema and burning 12 hours after the injection, as well as occasional little hematomas.
Several strategies may help to prevent or manage the occurrence of adverse events after skin priming with PN-HPT™ gels. The main recommendations are:
Avoid exposure to natural sunlight or to sun lamps for 48 hours;
Apply soothing creams and ice packs, and use topical anaesthetics (eg, lidocaine) to reduce the discomfort associated with needle injections.
Aftercare
Avoid touching the treated areas for 6 hours after the treatments
After that the area can be washed with a gentle cleanser
Avoid makeup for 24 hours
Avoid strenuous exercises and swimming to avoid risk of infection
Avoid alcohol consumption for 24 hours before and after the treatments
Apply mineral SPF 30 or 50
Until the initial swelling and redness have resolved, do not expose the treated areas to intense heat (eg. sauna, steam rooms, hot showers, and sunbathing) or extreme cold
Further Reading and References
Cavallini, M., Bartoletti, E., Maioli, L., Massirone, A., Pia Palmieri, I., Papagni, M., Priori, M., Trocchi, G. and As Members of The Polynucleotides HPT™ Priming Board, Collegio Italiano delle Società Scientifiche di Medicina Estetica (Italian College of the Aesthetic Medicine Scientific Societies)—SIME, AGORÀ, SIES, 2021. Consensus report on the use of PN‐HPT™(polynucleotides highly purified technology) in aesthetic medicine. Journal of Cosmetic Dermatology, 20(3), pp.922-928.
Cavallini, M., De Luca, C., Prussia, G. and Raichi, M., 2022. Retracted: PN‐HPT®(Polynucleotides Highly Purified Technology) in facial middle third rejuvenation. Exploring the potential. Journal of Cosmetic Dermatology, 21(2), pp.615-624.
Noh, T.K., Chung, B.Y., Kim, S.Y., Lee, M.H., Kim, M.J., Youn, C.S., Lee, M.W. and Chang, S.E., 2016. Novel anti-melanogenesis properties of polydeoxyribonucleotide, a popular wound healing booster. International Journal of Molecular Sciences, 17(9), p.1448.